Prosci Lag3 antibody: improve in vitro research and help cancer immunotherapy

French immunologist Triebel On 1990 First discovered in LAG-3 Immune control mechanism , His research team proved for the first time , Soluble LAG-3 Molecules pass through MHC II Signal transduction activates antigen presenting cells , Promote antigen specificity T Cellular response . However , About MHC II Whether the molecules are regulated separately LAG-3 The inhibitory function of is still controversial .  

Lymphocyte activating gene -3（LAG-3,LAG3） Is a member of the immunoglobulin superfamily , Combine with high affinity MHC II class , Negative regulation T Cell function and homeostasis . It's in B、T、NK cells 、 It is expressed in monocytes and dendritic cells , And play a regulating role T Role of cell proliferation .LAG-3 It is also an important immune checkpoint protein , resist LAG-3 Antibodies can activate T Effector cells and affect regulatory T Cell function . Besides ,LAG-3 It seems to be with PD-1/PD-L1 Work in a collaborative way , This suggests that the double antibody method may prove useful in cancer immunotherapy .  

AI Meijie ProSci  Characteristic immune checkpoint research related ：LAG3 antibody （ For scientific and academic purposes only , Not for medical and diagnostic purposes ） Aimed at improving in vitro research . Unlike antibodies developed using proteins made in yeast or bacteria , these LAG-3 Antibodies are developed using antigens expressed in mammalian cell lines , Post translational modification of natural proteins . It can be applied to application types that have been tested and verified .

 

chart ：LAG-3 In high expression HEK293 Immunofluorescence studies in cells use 2μg/ml Of LAG-3 antibody .

AI Meijie ProSci LAG3 Antibody related research program ：

LAG3 Antibody [2G8] RF16082  Mouse monoclonal antibody  E, Flow, ICC, IF, IHC-P, WB

LAG3 Antibody [7A7] RF16083  Mouse monoclonal antibody  E, Flow, ICC

LAG3 Antibody [9F9] RF16084  Mouse monoclonal antibody  E, Flow, ICC, IF, IHC-P

LAG3 Antibody [6B12] RF16086  Mouse monoclonal antibody  ICC, IF, IHC-P

LAG3 Antibody [6D1] RF16087  Mouse monoclonal antibody  ICC, IF, IHC-P

LAG3 Antibody [5F11] RF16088  Mouse monoclonal antibody  E, Flow, ICC, IF, IHC-P, WB

LAG3 Antibody [1G4] RF16089  Mouse monoclonal antibody  E, Flow, ICC, IF, IHC-P, WB

LAG3 Antibody 8655  calretinin  E, IF, IHC-P, WB

LAG-3 Recombinant Protein RF16080-01  Recombinant protein  biological assays