Paclitaxel loaded tpgs reduced albumin nanoparticles /ga-hsa gambogic acid human serum protein nanoparticles

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Paclitaxel loaded tpgs Preparation of reduced albumin nanoparticles ：
The preparation synthesized TPGS- Reducing albumin , Taxol ,TPGS- Reduced albumin and water for injection are made into paclitaxel coated TPGS- Reduced albumin nanoparticles , The preparation can form high loading nanoparticles , Improve enrichment through passive targeting .

GA-HSA Preparation of gambogic acid human serum protein nanoparticles ：
Adopt new albumin nano preparation technology (NabTM) Preparation of gambogic acid albumin nanoparticles (GA-HSA NPs), The morphology of nanoparticles was observed by transmission electron microscope , use Nicomp TM PSS 380 The particle size distribution and potential were measured by particle size analyzer , The encapsulation efficiency was determined by ultracentrifugation , Loading rate and film passing efficiency , The dilution stability and storage stability were also investigated . result GA-HSA NPs Under the electron microscope, it appears as spherical particles , The particle size is (103.2±34.4)nm,zeta Potential is -25.10 mV,GA-HSA NPs It has high encapsulation efficiency and membrane passing efficiency .GA-HSA NPs Freeze dried powder injection storage 12 There is no collapse or shrinkage during months ,GA-HSA NPs Suspension in storage 6 There is no significant change in particle size in the week .

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Ruixi YWX.2022.7.18