3D printing microstructure

As one of the application directions of stem cells, the direction of tissue and organ like organs , There has been some research in recent years . It is hopeful to solve the thorny problems such as the source of organ transplantation in the future .

3D Print

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3D Print （3DP） That is a kind of rapid prototyping technology , Also known as additive manufacturing , It is based on a digital model file , The use of powder like metal or plastic and other bindable materials , The technique of constructing objects by printing them layer by layer .

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3D Printing is usually realized by digital technology material printer . It's often made in molds 、 Fields such as industrial design are used to make models , Later, it was gradually used in the direct manufacturing of some products , There are already parts printed using this technology . The technology is in jewelry 、 The footwear 、 industrial design 、 Architecture 、 Engineering and construction （AEC）、 automobile , Aerospace 、 Dental and medical industries 、 education 、 Geographic Information System 、 Civil Engineering 、 Guns and other fields have applications .

Medical applications , As early as 2019 year 1 month 14 Japan , The University of California at San Diego is the first to use fast 3D Printing technology , To create a spinal stent that mimics the structure of the central nervous system , It helps the rats recover their motor function .

3D Print biomedical applications

1. organ , It can solve the problem of restraining the shortage of sources
2. Organoid , It can be used in drug screening and other fields
3. organization , Skin tissue , Vascular tissue, etc

3D Printing and micro organ

3D Print cardiac tissue - Simulate myocardial fiber structure

2020 University of California, San Diego Shaochen Chen The professor's laboratory is 《Biomaterials》 The magazine published the title Direct 3D bioprinting of cardiac micro-tissues mimicking native myocardium Research paper of . The authors use digital light processing 3D Bioprinting technology and gelatin derived materials mixed with high concentration of myocardial cells （GelMA）, Print out the set material pattern to induce the arrangement of myocardial cells and fibers in the mouse ventricle （ chart 1）. The total length of myocardial tissue printed is about 2 centimeter , wide 1 centimeter , thick 250 micron . Myocardial tissue is suspended in two simultaneously printed micro pillars （micro-cantilever） middle , To calculate myocardial contractility by measuring strut displacement .

3D Print chips create brain tissue

2021 year 4 month 6 Reported Wednesday , According to the report published on Tuesday 《 Biological microfluidics 》 A study in the Journal , A group of researchers used 3D The print chip produces a small amount of brain tissue , The so-called organoids .

3D Print spinal cord stents

2019 Years published in 《 natural · Medical Science 》 A paper published in the magazine said , For the first time, they used fast 3D Printing technology , To create a spinal stent that mimics the structure of the central nervous system , After loading neural stem cells, they were implanted into the spinal column of rats with severe spinal cord damage , It helps the rats recover their motor function .

3D Print teeth

From Griffith University in Australia (Griffith University)Menzies A periodontal specialist at the Institute Saso Ivanovski It is planned to use a biological printer to grow the missing gingival tissue or bone from the patient's own cells .

reference

1. http://www.cankaoxiaoxi.com/science/20210408/2439838.shtml
2. Direct 3D bioprinting of cardiacmicro-tissues mimicking native myocardium.
3. https://www.cn-healthcare.com/articlewm/20160405/content-1001912.html