People who lose weight should cry: it's no good not eating food, because your brain will be inflamed

Wanbo From the Aofei temple
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I want to eat delicious food but worry about getting fat , Take a look and satisfy the desire of your eyes , It's always harmless ？

Presumably, this is the true idea of many people who lose weight .

But！ You may want to be simple , Just look and don't eat , Although it can reduce energy intake , But it is still harmful to the body .

The latest research from the University of Basel in Switzerland shows , For obese people , Lose weight only by watching and not eating , It might make you Insulin secretion disorder , Impact on health .

And the mechanism behind this result , In your brain ：

Just look and don't eat , It can inflame the brain

The researchers found that , The key to control insulin secretion before or at the beginning of a meal , It's called Interleukin 1β Our cytokines , And this cytokine , It can be in the brain Cause inflammation , So as to stimulate the secretion of insulin .

The research team conducted clinical experiments on mice , The above conclusion is confirmed .

The whole experiment , That's true .

First , The research team prepared two groups of experimental mice , As the experimental group and the control group .

The night before the experiment , The research team tested two groups of mice 12 An hour's fast , To ensure that the food can stimulate them enough .

after , Two groups of mice were put into two cages , One of the cages is prepared with food , Another cage placed rubber particles similar to the size of food .

Just the first time the rats in the experimental group ate , Researchers collected blood samples from mice , Results show , The blood glucose of the experimental group did not increase significantly , But the concentration of insulin increased significantly .

By comparison , The insulin concentration in the control group did not increase .

The result of the experiment proves that 2 Fact ：

First , The moment the mouse sees the food , Insulin secretion caused by nerve stimulation has already occurred , During this period, experiencing stimulation causes insulin secretion , Also called by researchers Cephalic phase / The first period （cephalic phase） Insulin secretion .

secondly , This initial stimulation requires a premise , That is, food must be real .

The problem here is , Substances that cause cephalic irritation , What is it ？

The research team put the object of suspicion on Interleukin 1β On the body .

Interleukin 1β It's a cytokine , It can cause inflammatory reaction , At the same time, this substance has been proved , It can stimulate insulin secretion after eating .

To prove the hypothesis , Researchers pre injected some mice IL-1 Recipient I Type a antagonist , To stop interleukin 1β It works .

Stimulated by the same food , The researchers found that , The increase of insulin concentration in mice injected with antagonists , Not as significant as non injected mice .

It also shows that , Interleukin 1β In insulin secretion before meals , Played a key role .

So the next question is , Interleukin before meals 1β, Where to come from ？ And how it works ？

The researchers found that , After initial stimulation , Interleukin in serum 1β The level is basically kept below the detection limit .

This also proves. , Interleukin after initial stimulation 1β There is only a rise in local areas .

After a series of gene editing experiments , This so-called local area , Namely The central nervous system , say concretely , Interleukin after initial stimulation 1β The birth of , Derived from CX3CR1（ Microglia , It's an immune cell ） And bone marrow cells .

Interleukin 1β After this inflammatory factor is produced , Stimulate vagal activity in a Glucose dependent manner , Cause temporary inflammation inside the brain , Stimulate insulin secretion .

For healthy people , This process is normal , But for obese people , Interleukin 1β Caused by excessive inflammatory response , On the contrary, it will cause the opposite result ：

Insulin secretion is inhibited .

The research team conducted a secondary analysis of previous studies on human cephalic insulin secretion , It is found that obesity has a significant negative effect on the effect of cephalic insulin secretion .

And this result , It has also been confirmed in experiments .

The research team conducted 2 Weeks of high-fat diet feeding , It was found that cephalic insulin secretion failed .

meanwhile , The researchers tested another group of mice for a period of 3 Weekly high-fat diet feeding , But the mice were injected with interleukin during feeding 1β antibody , Results there was no problem with cephalic insulin secretion .

It turns out that , Obesity causes Endogenous interleukin 1β Long term excess of activity , It will make human and mouse cephalic insulin secretion disorder , And in this case , You can use interleukin 1β Antibodies for prevention .

therefore , Pot friends with too much meat , Don't think about just watching and not eating diet .

Originally, interleukin in the body 1β Excess , Stimulate more interleukin 1β produce , The result can only be insulin secretion disorder , Affect your health .

After all “ Keep your mouth shut and your legs open ” Most effective .

Last , I wish you all success in losing weight ～

Author of the paper

The research team is from the University of Basel, Switzerland , The research results have been published in Cell Metabolism On .

Corresponding author Sophia J. Wiedemann, Doctor of biomedicine and philosophy , Former president of the Swiss Medical Doctor Association , The main research fields include human metabolism 、 Immunology and food intake physiology .

Reference link ：

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00221-2#secsectitle0010